Granulosis rubra nasi is a rare condition characterised by hyperhidrosis of the nose. Granulosis Rubra Nasi (GRN) is a rare disorder of the eccrine glands. It is clinically characterized by hyperhidrosis of the central part of the face. Granulosis rubra nasi is a rare familial disease of children, occurring on the nose, cheeks, and chin, characterized by diffuse redness, persistent excessive.

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In the case of perioral dermatitis there are small monomorphic papules, pustules, erythema, and scaling involving the perioral area and no hyperhidrosis. Eccrine hidrocystoma also shows dilatation of sweat glands with solitary or multiple cysts lined by a double layer of cuboidal cells on histology, but dilatation of dermal vessels and perivascular mononuclear infiltrate is not seen [ 4 nassi, 10 ].

Granulosis rubra nasi is a rare disorder of the eccrine glands first described by Jadassohn in However, erythema over the central face was persisting. The authors believe that inflammation around sweat ducts are responsible for decreased sweating and hence, vesicle formation- findings in the late stage of GRN.

She had first noticed redness and increased sweating over central face 10 years back.

Please review our privacy policy. We are not in a position to comment on the response of tacrolimus in earlier stages of disease process, when hyperhidrosis is prominent as we got the patient in a very late stage. Disorder of eccrine glands, granulosis rubra nasi, telengiectasia.

There was no history of any fluid or cheesy material coming out of the lesions and no history of itching or burning Figure 1. Our patient presented with granulosis rubra nasi, a rare disease. Two cases of granulosis rubra nasi in boys. Please follow this link if you have any high-quality images that you granulosls contribute to the website.


Hyperhidrosis and botulinum toxic in dermatology. The diagnosis is largely clinical. The patient was reassured taking into granulosjs the benign nature of the disease. Few telangiectatic blood vessels were noted on and around the nose. Retrieved from ” https: Hirsutism Acquired localised generalised patterned Congenital generalised localised X-linked Prepubertal.

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Correspondence should be addressed to Farhana Tahseen Taj ; moc. However, telangiectatic blood vessels and some erythema were still persisting. After another three months of follow grwnulosis, patient had not developed any new lesions and had not experienced any significant side effects of Tacrolimus.

Within 1 year, she developed multiple erythematous papules patient stated lesions did not express fluid or whitish material on excoriation over nose and cheeks. Hidrocystoma is characterized by cystic papules of about 1—3 mm in diameter usually appearing in the periorbital area of middle-aged or elderly women. Shows erythema more prominently. Ueber die Beziehungen des Hidrocystoms zur Granulosis rubra nasi.

The clinical picture is very distinctive and rarely there is a problem with the diagnosis. This is followed by appearance of diffuse erythema over the nose, cheeks, chin, and upper lip.

This is an open access article distributed under the Granluosis Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Histopathology shows a mild mononuclear cell infiltrate around the sweat ducts, blood vessels, and lymphatics. A Patchy mononuclear cell infiltration in upper dermis with dilatation of capillaries and lymphatics Haematoxylin and Eosin stain x granulois B patchy mononuclear cell infiltration with dilatation of capillaries and lymphatics Haematoxylin and Eosin stain x ; C mononuclear cell infiltration around rubea duct Haematoxylin and Eosin stain x Open in a separate window.


Patient had noticed decreased sweating over the area, once vesicles started to appear. It is seen over tip of nose and sometimes, cheeks. Rashid, Granulosis rubra nasihttp: GRN usually resolves at puberty; however, rarely it may persist in adulthood. These lesions disappear on diascopy and reappear on relieving pressure [ 2 ].

Granulosis Rubra Nasi Response to Topical Tacrolimus

Recently, use of botulinum toxin A that induced long-term remission in a patient with GRN was described by Grazziotin et al. Histopathology from the vesicle revealed mononuclear cell infiltration in the upper dermis along with dilatation of superficial capillaries and lymphatics Figure 2 A,B.

Granuloss cream was stopped fearing ocular side effects; however, Tacrolimus ointment was continued. A provisional diagnosis of Granulosis rubra nasi was made, and hidrocystoma and rosacea were considered as differential diagnosis. There is dilation of blood vessels and the lymphatic vessels.

Granulosis rubra nasi: a rare condition treated successfully with topical tacrolimus

There was history of summer aggravation; however, she was never lesions free, even granklosis winter months.

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Granulosis rubra nasi is a rare condition characterised by hyperhidrosis of the nose.