Sign of Leser-Trélat. Authoritative facts about the skin from DermNet New Zealand. Leser-Trélat sign is a rare skin condition characterized by the sudden appearance of seborrheic keratoses that rapidly increase in number and size within weeks. Images in Clinical Medicine from The New England Journal of Medicine — The Sign of Leser–Trélat.

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Patients with asymptomatic lesions require no further treatment for the seborrheic keratoses besides the treatment of trelar malignancy. Malignant involvement of the skin and the genodermatoses.

Malignant Neoplasms and the Leser-Trélat Sign | JAMA Dermatology | JAMA Network

Possible role of retinoid therapy. Sign in to save your search Sign in to your personal account. Create a free personal account to download free article PDFs, sign up for alerts, and more.

Aldrich-Mees’ lines Beau’s lines Muehrcke’s lines Terry’s nails.

Leser–Trélat sign – Wikipedia

Bernett ; George J. Published by Wolters Kluwer – Medknow. Beitrage zur Fruhdiagnose des Darmcarcinomas Hereditatsverhaltnisse und Hautveranderungen. Kilickap S, Yalcin B. In addition, symptomatic lesions may be destroyed with various physical methods including cryotherapy, curettage, shave removal, and electrodesiccation.

Cutaneous markers of internal malignancy. Obtaining a thorough history, review or systems, and physical examination may help direct the workup of the patient towards a certain malignancy. Kurzrock R, Cohen PR.


Leser–Trélat sign

Although most associated neoplasms are gastrointestinal [4] adenocarcinomas stomachlivercolorectal and pancreasmalignancies of the breastlung[5] and urinary tract[6] as well as lymphoid tissue, have been associated with this impressive rash.

Jpn J Med ; Article by Robert A Schwartz”. CA Cancer J Clin ; Ueber ein die Krebskrankheit beim Menschen haufig begleitendes, noch wenig gekanntes Symptom. The Oxford illustrated companion to medicine. None, Conflict of Interest: Two months before, she had noticed the sudden appearance of many “warts” on her face and neck.

Granulocytosis Multicentric reticulohistiocytosis Nonbacterial thrombotic endocarditis. Questions To access free multiple choice questions on this topic, click here. Gharwan H, Gradon JD.

Additional named growth factors include human-growth-hormone, transforming growth factor-alpha, and insulin-like growth factor. They are well-circumscribed pigmented lesions with the color ranging from skin tone to tan or brown, and some lesions may appear black.

Multiple eruptive seborrheic keratoses on the a face and neck, b breast, and c back Click here to view. Differential Diagnosis Eruptive seborrheic keratoses have been reported in numerous other clinical scenarios including in patients with erythroderma, pregnant patients, HIV-infected patients, and transplant patients.

Eruptive seborrheic keratoses have been reported in numerous other clinical scenarios including in patients with erythroderma, pregnant patients, HIV-infected patients, and transplant patients. Cutaneous manifestations of internal malignancy. Create a free personal account to access your subscriptions, sign up for alerts, and more. Create a personal account to register for email alerts with links to free full-text articles. They appear as brown warty nodules with a stuck-on appearance.


A possible role of a cutaneous marker for internal malignancy. Paraneoplastic dermatological manifestation of gastrointestinal malignancies. Create a free personal account to make a comment, download free article PDFs, sign up for alerts and more.

The associated cancer is often advanced and the average survival of these patients is approximately However, the sudden eruption of seborrhoeic keratoses in young patients points to a paraneoplastic process and should prompt an investigation for a hidden cancer. The presence of horn cysts on the surface of the lesions is also classic.

The sign of Leser-Trelat. Narala S, Cohen PR. Affilations 1 Orange Park. Seborrheic keratoses and cancer. It is thought that paraneoplastic syndromes are caused by the release of hormones from the tumour but this remains to be proven.

Self-skin examination New smartphone apps to check your skin Learn more Sponsored content. Images in clinical medicine. Views Read Edit View history.

Because seborrhoeic keratoses and cancer are both statistically more common in elderly people it is difficult to ascertain whether the keratoses is due to the cancer ie: StatPearls Publishing ; Jan.